Cancer-Stalling System Accelerates AgingReference: Cancer-Stalling System Accelerates Aging. Science. 4 Jan 2002. Vol 295.
This article describes research done with genetically engineered mice. The researchers were investigating the effects of the p53 protein and created a mutated gene for the p53 protein that seemed to amplify the effects of p53 in those mice.
Carefully read the article then answer these questions.
- How does p53 prevent cancer ?
- What happens if you don't have sufficient p53 protein ?
- How many of the mutant (altered p53) mice developed tumors while they were alive ? ___________
- How many of the normal (both copies of the p53 gene intact) mice developed tumors ? ___________
- How many weeks did it take for ½ of the mutant (super p53) mice to die ? ___________
- How many weeks did it take for ½ of the normal mice to die ? ___________
- How long did the oldest mutant (super p53) mice live ? ___________
- How long did the oldest normal mouse live ? ___________
- What happens when you knock out the p53 gene completely?
- Describe the trade-off the article discusses that seems to exist with the p53 protein.